 | 制药
目前本页还没有简体中文版。您可以使用Google的翻译服务查阅
自动翻译。
我们不负责提供该项服务，而且翻译结果未经过我们的检查。 Raman spectroscopy fulfils a critical analytical role at many stages of the pharmaceutical product design and production process. Applications range from monitoring and controlling large scale manufacturing processes, to profiling the distribution of active pharmaceutical ingredients (API) and excipients at different stages in a formulation cycle.
The illustration shows StreamLine™ Plus chemical images of a pharmaceutical tablet. The image of the complete tablet was collected in 4 minutes, with the image generated from greater than 10,000 individual spectra. The data sets were subsequently analysed using a chemometric technique to identify the three APIs. For more detail on this analysis, and further information on topics related such as high throughput screening (HTS), polymorph discrimination, FDA 21 FDA Part 11 compliance, please download the relevant document. Raman is particularly suited to combining with other analytical techniques given that it provides non-destructive analysis requiring little or no sample preparation, and offers unparalleled polymorph discrimination, is capable of studying aqueous and solid samples. Please note that document downloads require registration. Documents for download
Selected publicationsDefining a strategy for chemical imaging of industrial pharmaceutical samples on Raman line-mapping and global illumination instruments (2006) Donald Clark et al, Applied Spectroscopy, 60, 494-502 Drug characterization in low dosage pharmaceutical tablets using Raman microscopic mapping (2006), Mark J. Henson et al, Applied Spectroscopy, 60, 11, 1247-1255 A comparison of Raman chemical images produced by univariate and multivariate data processing—a simulation with an example from pharmaceutical practice (2004), Slobodan a i et al, Analyst, 129, 1001–1007 |
