生命科学资料

The domain of biological research is shaped by our ability to peer into the world of the small. Simply seeing microscopic biological samples is useful, but by utilising Raman spectroscopy we can surpass sight into the molecular realm… and beyond! Download this brochure to discover the wealth of biological applications made possible by Renishaw's Raman systems.

Brochure: Biological analysis using Raman spectroscopy and imaging

The domain of biological research is shaped by our ability to peer into the world of the small. Simply seeing microscopic biological samples is useful, but by utilising Raman spectroscopy we can surpass sight into the molecular realm… and beyond! Download this brochure to discover the wealth of biological applications made possible by Renishaw's Raman systems.

[2.4MB]

Raman spectroscopy is sensitive to the presence of haem proteins and is ideal for studying their redox biology, without the need for isolation or staining. The redox of haem proteins is closely linked to their protein functions – oxygen transport and storage, electron transport, and scavenging of free radicals. By using Raman spectroscopy to elucidate redox states within biological systems, researchers can study redox dynamics and its effects on health regulation and diseases.

Application note: Redox biology with the inVia confocal Raman microscope

Raman spectroscopy is sensitive to the presence of haem proteins and is ideal for studying their redox biology, without the need for isolation or staining. The redox of haem proteins is closely linked to their protein functions – oxygen transport and storage, electron transport, and scavenging of free radicals. By using Raman spectroscopy to elucidate redox states within biological systems, researchers can study redox dynamics and its effects on health regulation and diseases.

[401kB]

Raman spectroscopy is an information-rich, label-free, non-invasive imaging technique that is ideal for life sciences research. It uses laser light scattering to provide a chemical fingerprint at each point of the analysed area and identifies the molecules present in samples.

Application note: Raman imaging for biological applications. No stains. No labels.

Raman spectroscopy is an information-rich, label-free, non-invasive imaging technique that is ideal for life sciences research. It uses laser light scattering to provide a chemical fingerprint at each point of the analysed area and identifies the molecules present in samples.

[509kB]

Renishaw’s microplate mapping package enables researchers to use Renishaw’s Raman spectroscopy products to rapidly and easily analyse material contained in microplates.

Product note: Microplate mapping with Renishaw Raman system's

Renishaw’s microplate mapping package enables researchers to use Renishaw’s Raman spectroscopy products to rapidly and easily analyse material contained in microplates.

[285kB]

Demonstrating discrimination between diseased and healthy brain tissue using the Renishaw RA816 Biological Analyser.

Application note: Classification of brain glioma tumours using the Renishaw Biological Analyser

Demonstrating discrimination between diseased and healthy brain tissue using the Renishaw RA816 Biological Analyser.

[384kB]

With Renishaw’s inVia confocal Raman microscope you can identify and characterise samples to provide chemical, spatial and structural information on multiple types of molecule, without labelling. It provides rich, detailed, chemical images and highly specific data at high spatial resolution, making it ideal for studying cells.

Application note: Cell imaging with the inVia confocal Raman microscope

With Renishaw’s inVia confocal Raman microscope you can identify and characterise samples to provide chemical, spatial and structural information on multiple types of molecule, without labelling. It provides rich, detailed, chemical images and highly specific data at high spatial resolution, making it ideal for studying cells.

[365kB]

Raman imaging is a powerful research tool for understanding the molecular composition, structure and distribution of different chemical species. Nano silver/gold colloids and roughened metallic substrates can be used to amplify the intensity of the Raman scattering of adsorbed molecules via SERS. This can increase the sensitivity and/or the specificity of the analysis. SERS imaging can be used to evaluate the efficacy of delivery of nanoparticles (NPs) into cells/animals. SERS measurement of labelled or surface-modified NPs can also be used for biosensing, multiplexing and theranostics.

Application note: Surface enhanced Raman spectroscopy (SERS) imaging using the inVia confocal Raman microscope

Raman imaging is a powerful research tool for understanding the molecular composition, structure and distribution of different chemical species. Nano silver/gold colloids and roughened metallic substrates can be used to amplify the intensity of the Raman scattering of adsorbed molecules via SERS. This can increase the sensitivity and/or the specificity of the analysis. SERS imaging can be used to evaluate the efficacy of delivery of nanoparticles (NPs) into cells/animals. SERS measurement of labelled or surface-modified NPs can also be used for biosensing, multiplexing and theranostics.

[333kB]

The December 2015 issue of 'The Pathologist' featured an article describing how Raman spectroscopy is a non-invasive way of obtaining morphological and chemical information about cells that may lead to better cancer research.

Portrait of a dying cell

The December 2015 issue of 'The Pathologist' featured an article describing how Raman spectroscopy is a non-invasive way of obtaining morphological and chemical information about cells that may lead to better cancer research.

[1.4MB]

Confirming the presence of a topical compound in the epidermis and reticular dermis with high specificity and sensitivity.

Application note: Monitoring transdermal drug delivery in skin using the RA816 Biological Analyser

Confirming the presence of a topical compound in the epidermis and reticular dermis with high specificity and sensitivity.

[705kB]

Demonstrating discrimination between diseased and healthy brain tissue using the Renishaw RA816 Biological Analyser.

Application note: Classification of brain glioma tumours using the Renishaw Biological Analyser

Demonstrating discrimination between diseased and healthy brain tissue using the Renishaw RA816 Biological Analyser.

[384kB]

Raman tissue imaging is a unique method that can simultaneously describe the molecular composition and the distribution of multiple chemical species in tissues at a high spatial resolution, without labelling.

Application note: Tissue imaging with the inVia Raman microscope

Raman tissue imaging is a unique method that can simultaneously describe the molecular composition and the distribution of multiple chemical species in tissues at a high spatial resolution, without labelling.

[466kB]

Product note detailing how you can perform Rayleigh imaging on the inVia confocal Raman microscope.

Product note: Rayleigh imaging using the inVia™ confocal Raman microscope

Product note detailing how you can perform Rayleigh imaging on the inVia confocal Raman microscope.

[1.7MB]

The Virsa™ Raman analyser is ideal for developing clinical applications of Raman spectroscopy. It is available with a clinically-ready fibre-optic probe developed in partnership with EmVision, leaders in medical fibre probes.

Application note: Virsa Raman analyser for in vivo studies

The Virsa™ Raman analyser is ideal for developing clinical applications of Raman spectroscopy. It is available with a clinically-ready fibre-optic probe developed in partnership with EmVision, leaders in medical fibre probes.

[317kB]

Raman imaging is an ideal technique for studying plant tissue in a non-destructive and non-invasive way. Raman images spatially resolve chemical and structural information, and can be acquired in the presence of water and in vivo. Here the spatial distribution of plant metabolites and tissue structure are revealed using the Renishaw inVia™ Qontor® confocal Raman microscope.

Application note: Raman imaging of plant metabolite crystals

Raman imaging is an ideal technique for studying plant tissue in a non-destructive and non-invasive way. Raman images spatially resolve chemical and structural information, and can be acquired in the presence of water and in vivo. Here the spatial distribution of plant metabolites and tissue structure are revealed using the Renishaw inVia™ Qontor® confocal Raman microscope.

[355kB]