化学科学资料
资料下载:化学科学(药物)
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样本: 药物分析解决方案
雷尼绍在拉曼光谱设备领域占据世界领先地位,有超过25年为全球客户提供拉曼系统的经验。我们是一家跨国公司,拥有遍布全球的科学家和工程师网络,可随时为您提供产品、应用和技术方面的专业支持。 我们深谙药物分析领域存在的诸多挑战,并基于客户的需求设计灵活的解决方案。无论您是新手还是专家,是配方设计员还是质量分析员,我们的系统都能满足您的需求。
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产品说明: RA802药物分析仪
RA802药物分析仪是一款紧凑型台式拉曼成像系统,它对配方分析进行了重新定义。RA802操作简单,能够揭示丰富的化学信息。 RA802是专为制药行业设计的,用于快速获取详细的化学物种分布信息。它采用雷尼绍独特的LiveTrack™实时聚焦追踪技术,能够以惊人的速度对凸凹不平、弯曲或粗糙的表面进行高效分析,无需任何样品制备。
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Application note: New methods for determining content uniformity of formulations [en]
Using the RA802 to monitor the uniformity of a drug product’s contents to ensure that the correct dose is delivered every time.
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Application note: Study the stability of pharmaceutical formulations with Raman microscopy [en]
Many pharmaceutical materials are highly sensitive to changes in temperature and humidity which can affect their crystalline structure. Knowing the stability of these polymorphs and hydrates, in different conditions, is critical to ensure products are safe, efficient and can be patent protected.
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Application note: Investigate pharmaceutical solid dose products using the inVia confocal Raman microscope [en]
With so many components and properties, determining the composition, domain size and distribution of patent-expired commercially available formulations is highly desirable. This information creates opportunities to replicate an existing product without the need for lengthy development and prohibitive costs.
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Application note: Transmission Raman for monitoring pharmaceuticals [en]
Whether at the research and development stage, or manufacturing, the inVia Raman microscope offers simple and fast transmission Raman analysis.
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Application note: Combined chemical and particle distribution analysis of pharmaceutical powders [en]
When formulating pharmaceuticals, it is important to understand the chemical composition and morphologies of the ingredients, as these can lead to changes in product performance. For example, active ingredient co-localisation and particle adhesion can affect the efficacy of formulation. This application note details how to use a Renishaw Raman system to conduct this type of analysis.
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Application note: Using Raman spectroscopy to tackle polymorphism, an industry problem [en]
This note looks at incidences of polymorphism in drug development including advantages and challenges.
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Application note: Raman imaging for deformulating a transdermal patch [en]
An application note detailing the RA802's ability to deformulate the make-up of a transdermal nicotine patch.
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Application note: Rapid polymorph identification with the RA802 Pharmaceutical Analyser [en]
Characterising the polymorphism of active pharmaceutical ingredients when developing a commercially viable product.
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Technical note: Quantitative Raman spectroscopy [en]
This document focuses on concentration measurements but the principles detailed are also applicable to other quantitative measurements, such as stress/strain.
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白皮书: 鉴伪— 使用拉曼成像技术鉴别假冒伪劣药品
监管当局以及制药公司愈来愈关注如何鉴别假冒伪劣药品。拉曼光谱具有高度特异性,能够区分化学结构相似的材料。拉曼光谱的特异性使它更适用于识别假冒伪劣药品,因为假冒伪劣药品通常与参照品成分相似。
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白皮书: 药物逆向工程分析方法
在本白皮书中,我们将介绍如何使用拉曼成像技术对现有药物制剂进行逆向工程分析。RA802能够成功鉴别原研药和仿制药,并加快药物逆向工程分析。RA802能够识别原研制剂的成分及其相对百分含量、颗粒尺寸和分布,方便仿制药制造商调整工艺,以制造出同等产品或者策略不同的产品。
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Technical note: Polymorph identification and qualification [en]
This technology note illustrates the benefits of combining dedicated analysis software with a high-performance Raman instrument and how Renishaw supplies an effective, user-friendly solution to provide complementary information to the multitude of established HTS techniques commercially available.
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Application note: Detecting small amounts of multiple API polymorphic forms in powder blends [en]
This note shows how the RA802 Pharmaceutical Analyser can be used to analyse a range of samples, such as powder blends and tablets, to screen for the presence and form of APIs
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Product note: Cluster analysis and data classification [en]
The ability to group highly similar spectral data is a key result for research areas including biology and medicine. It enables qualitative conclusions to be drawn objectively based on statistics, rather than subjectively based on an analyst’s experience.
资料下载:化学科学(高分子聚合物)
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Application note: Analysing microplastics with the inVia™ confocal Raman microscope [en]
Plastics are extensively used in products and packaging and, unfortunately, make their way into the environment, causing significant issues for wildlife. In addition to concerns about bulk plastic contamination, there has been much interest in microplastics. Raman spectroscopy, an optical scattering technique, has much to offer researchers investigating plastics, as it can identify them rapidly and non-destructively.
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Application note: Study polymers with the inVia confocal Raman microscope [en]
The Renishaw inVia confocal Raman microscope is ideal for the 2D and 3D chemical analysis of polymers. Synthetic polymers display a broad range of properties and are extensively used in modern products. The study of polymers in terms of identification, spatial distribution and concentration is important as we search for novel materials, improve effectiveness of existing materials, and reduce the costs of products. The inVia microscope provides chemical specificity and sensitivity, in a non-destructive manner, with no sample manipulation and preparation required.
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Technical note: Using the inVia Raman microscope for locating and characterising microplastics [en]
Renishaw’s inVia confocal Raman microscope is ideally suited to the analysis of microplastics. A combination of optical and Raman imaging techniques with Renishaw's WiRE software are used to locate, image and characterise particles.
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Application note: Analysis of polymer fibres using the Virsa™ Raman analyser [en]
Application note detailing how the Virsa Raman analyser can be used to analyse polymer fibres.
资料下载:化学科学(化学制品)
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Application note: Study emulsions using the inVia confocal Raman microscope [en]
The Renishaw inVia confocal Raman microscope is the ideal system for the complete 2D and 3D chemical analysis of emulsions and colloids.
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Application note: Analyse coatings with the inVia™ confocal Raman microscope [en]
Chemically characterise your coatings with Renishaw’s inVia confocal Raman microscope. It is the ultimate system for studies ranging from fundamental research on the materials involved through to final product quality control and failure analysis.
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Application note: Analysing liquids with the Virsa™ Raman analyser [en]
Application note showing how easy it is to analyse liquids with the Virsa Raman analyser
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Application note: Monitoring phase changes [en]
Monitoring the crystallographic phase changes of potassium nitrate using the inVia Raman microscope
资料下载:化学科学(催化)
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Application note: Analysing catalytic powders with the Virsa™ Raman analyser [en]
Application note detailing how the Virsa Raman analyser can be used to study catalysts, with vanadium oxide as an example.
视频
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StreamHR Rapide - nasal spray [en]
Using a Renishaw inVia confocal Raman microscope and WiRE™ software to image a drop of nasal medication. The image build up is shown at true data collection speed using StreamHR Rapide.
应用案例
我们有各种各样的应用案例,举例如下。
如需了解更多信息,请点击下方按钮联系当地的业务代表,并提供相应的文档编号。
文档编号 | 文档说明 |
AS008 | 洗衣粉成像 使用inVia StreamLine成像,揭示混合粉末信息。在此案例中量化了大面积粉末中的单组分区域及其分布。 |
AS009 | 药片成像 使用inVia StreamLine成像,揭示药物配方信息。在此案例中量化了整个药片区域中的药物活性成分 (API) 区域及其分布。 |
AS010 | 吸入剂成分成像 使用inVia StreamLine成像,揭示药物配方信息。在此案例中,拉曼分辨出吸入剂的药物活性成分 (API),并比较了它们的相对位置。 |
AS011 | 对包被的喷鼻剂颗粒进行成像 使用inVia StreamLine成像,揭示药物配方信息。在此案例中,拉曼光谱分辨出喷鼻剂颗粒。药物活性成分 (API) 包覆在辅料载体颗粒外。 |
AS012 | 多聚物层合板的3D成像 使用inVia和3D成像,揭示多层聚合物膜信息。 |
AS015 | Pirinase喷鼻剂成像 使用inVia StreamLine成像,揭示药物配方信息。在此案例中量化了Pirinase微滴中的API区域及其分布。 |
AS018 | 分析聚乙烯中的LA模 使用inVia,呈现低波数的拉曼谱带。在此案例中,显示出高密度聚乙烯的纵向声模 (LAM)。 |
AS019 | 分析硫磺的晶格模 使用inVia,呈现低波数的拉曼谱带。在此案例中,显示出硫磺的晶格模 (LAM)。 |
AS020 | 分析气体的旋转模 使用inVia,呈现低波数的拉曼谱带。在此案例中,观察到空气峰的旋转模。 |
AS022 | 在高分辨率下分析Piriton的成分 本案例分析展示了,如何使用inVia以高分辨率表征整个药片的成分。 |
AS029 | 低波数拉曼成像 低波数拉曼谱带包含重要的化学和结构信息。通常使用带有三重衍射光栅的光谱仪观察低波数的拉曼谱带,但由于拉曼信号强度不足,而无法成像。雷尼绍Eclipse滤光片使低波数拉曼谱带的成像变得简单。 |
AS032 | 在高分辨率下量化SINGULAIR®药片的成分 利用inVia的高分辨率StreamLine™成像功能,可以改进对药物活性成分 (API) 区域尺寸和含量的量化精确度。SINGULAIR®(一般称为孟鲁司特钠)是用于缓解哮喘和过敏性鼻炎症状的药物。在此案例中,对SINGULAIR®中的API区域进行了量化和对比。不同空间分辨率图像显示了生成大面积、高分辨率数据的好处。 |
AS054 | 酸奶的共聚焦拉曼成像 酸奶的拉曼成像能够提供其蛋白质-类脂网络信息、脂质和水合的堆积顺序,而无需染色。 |