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Ground breaking Raman work presented at conference

June 2018

Renishaw has collaborated with scientists at Oxford Radcliffe Hospital to investigate the capability of Raman spectroscopy to classify gliomas, in terms of their genetic subtypes, using different pathological preparations. This work was presented at the recent Cancer Research UK Brain Tumour Conference, 2018 held in London from 1-3 May 2018.

James Livermore, a Clinical Research Training Fellow in the Nuffield Department of Clinical Neuroscience at the University of Oxford, presented a poster titled “Genetic classification of gliomas using Raman spectroscopy”. The poster was co-authored by Oxford University colleagues from the Department of Neurosurgery and Neuropathology, the Department of Chemistry, and experts from Renishaw.

The work highlighted the potential use of Raman spectroscopy for rapid, intra-operative glioma genetic classification. The genetic sub-classification of glioma tumours is essential for pathological diagnosis and prognostication. Current methods for genetic classification include immunohistochemistry with a mutation-specific antibody and targeted DNA sequencing, which take several days to complete. In this study, Raman spectroscopy showed the potential to provide a non-invasive and non-destructive tool to probe the unique molecular vibrations of tissue samples, allowing for rapid sample analysis to aid in clinical decision making.

Renishaw's new Biological Analyser has shown that with further research it has the future potential to aid surgeons to tailor their surgical strategy based on a patient's specific tumour genetics.

Renishaw's Biological Analyser enables the rapid collection of detailed information on biological samples, without the need for complex sample preparation. Find out how Renishaw's Raman instruments can be used for biological research by visiting www.renishaw.com/bio

More information about the conference can be found at http://www.cancerresearchuk.org/funding-for-researchers/research-events-and-conferences/brain-tumour-conference-2018

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